# | Official Title | Conditions | Countries | Year | Enrollment | Interventions | Location |
---|---|---|---|---|---|---|---|
1 | A Comparative Effectiveness Study of Cancer Risk Management for Women at Elevated Genetic Risk of Ovarian Cancer | Fallopian Tube Carcinoma, Hereditary Breast and Ovarian Cancer Syndrome, Ovarian Carcinoma, Primary Peritoneal Carcinoma | United States | 2100 | 2 605 | Evaluation of Cancer Risk Factors, Medical Chart Review, Study of Socioeconomic and Demographic Variables | GOG Foundation |
2 | Specialized Program of Research Excellence (SPORE) in Endometrial Cancer | Lynch Syndrome, Recurrent Uterine Corpus Carcinoma, Stage III Uterine Corpus Cancer, Stage II Uterine Corpus Cancer, Stage I Uterine Corpus Cancer, Stage IV Uterine Corpus Cancer | United States | 2100 | 3 600 | Laboratory Biomarker Analysis | GOG Foundation |
3 | The Relationship of Racial Genetic Admixture With Endometrial Cancer Outcomes | Stage III Uterine Corpus Cancer, Stage II Uterine Corpus Cancer, Stage I Uterine Corpus Cancer, Stage IV Uterine Corpus Cancer | United States | 2100 | 243 | Laboratory Biomarker Analysis, Study of Socioeconomic and Demographic Variables | GOG Foundation |
4 | The Role of Synuclein-gamma (SNCG) in the Carcinogenesis of Uterine Papillary Serous Carcinoma | Endometrial Serous Adenocarcinoma, Stage III Uterine Corpus Cancer, Stage II Uterine Corpus Cancer, Stage I Uterine Corpus Cancer, Stage IV Uterine Corpus Cancer | United States | 2100 | 360 | Diagnostic Laboratory Biomarker Analysis, Immunohistochemistry Staining Method, Medical Chart Review, Microarray Analysis, Study of Socioeconomic and Demographic Variables, Western Blotting | GOG Foundation |
5 | Topoisomerase 2-Alpha (TOPO2A) Genomic Alterations and Immunohistochemical Expression as Well as Chromosome 17 Polysomy in Advanced or Recurrent Endometrial Carcinoma Treated With Anthracycline-Based Therapy | Recurrent Uterine Corpus Carcinoma, Stage III Uterine Corpus Cancer, Stage IV Uterine Corpus Cancer | United States | 2100 | 169 | Laboratory Biomarker Analysis | GOG Foundation |
6 | Effects of Cannabidiol on Psychiatric Symptoms, Cognition, and Cannabis Consumption in Cannabis Users With Recent-Onset Psychosis | Cannabis Use, Schizophrenia Spectrum Disorders | United States | 2050 | 0 | Cannabidiol (CBD), Placebo | University of Maryland, Baltimore |
7 | Prospective Cohort Study of the AQUACEL™ Ag SURGICAL Cover Dressing in Total Knee Replacement Surgery | Osteoarthritis | 2050 | 0 | Aquacel Ag dressing | Golden Jubilee National Hospital | |
8 | National, Multicenter, Randomized, Double-blind, Triple-dummy, Phase II Clinical Trial to Evaluate the Efficacy and Safety of Canadá Association in the Treatment of Chronic Pain | Pain, Chronic | 2026 | 168 | Canadá, Canadá placebo, Dipyrone, Dipyrone placebo, Tramadol hydrochloride, Tramadol hydrochloride placebo | EMS | |
9 | Open-trial to Prospectively Test the Feasibility of a Precision Psychotherapy System for Low-income Patients | Agoraphobia, Dysthymic Disorder, Generalized Anxiety Disorder, Major Depressive Disorder, Panic Disorder, Social Anxiety Disorder, Specific Phobia | 2026 | 111 | Pre-treatment psychotherapy recommendations | National Council of Scientific and Technical Research, Argentina | |
10 | Efficacy of Local Delivery of MicroRNAs and MicroRNA Inhibitors in Promoting Osteogenesis and Modulating Local Inflammation: A Pilot Clinical Trial Using the Tooth Socket Model | Tooth Extraction Status Nos | United States | 2025 | 0 | 10µg of PMIS miR200a plasmids, 10µg of pSil-miR200c, 5µg of pSil-miR200c and 5µg of PMIS miR200a, Anesthesia, Biodegradable sponge (type I bovine collagen), Blood, CBCT scan, clinical measurements, cross mattress suture, periapical xray, Photos/videos, PVS impression, saliva, tooth extraction, Wound fluid | University of Iowa |
11 | Outcomes of Low-dose Colchicine in Patients With Myocardial Infarction: A Randomized Controlled Trial | Myocardial Infarction, Myocardial Ischemia, Myocardium; Injury | Pakistan | 2025 | 800 | Colchicine, Placebo oral tablet | Shifa Tameer-e-Millat University |
12 | The Effect of Lumify™ (Brimonidine Tartrate Ophthalmic Solution 0.025%) on Ocular Redness, Intraocular Pressure, and Eyelid Position in Glaucoma Patients Using Brimonidine 0.2%, 0.15%, or 0.1% | Droopy Eyelid, Glaucoma, Glaucoma; Drugs, Glaucoma, Open-Angle, Glaucoma, Primary Open Angle, Ptosis | United States | 2025 | 60 | brimonidine tartrate ophthalmic solution 0.025%, sterile balanced saline solution | Tulane University |
13 | A Randomized, Double-Blind, Placebo Controlled, Multi-Center Study of Sodium Hyaluronate to Provide Symptomatic Relief of Lateral Epicondylosis (Tennis Elbow) | Epicondylitis, Epicondylosis, Tennis Elbow | 2025 | 168 | OVT (Sodium Hyaluronate), Saline | Anika Therapeutics, Inc. | |
14 | Assessment of an Integrated Continuous Glucose Monitor and Insulin Injection Port in Type 2 Diabetes | Type 2 Diabetes Treated With Insulin | 2025 | 18 | Use of novel insulin injection port | Pacific Diabetes Technologies | |
15 | Age-independent Decline in Manual Dexterity of Middle-aged and Older Adults | Aging | United States | 2025 | 0 | Force control practice, Pegboard practice | University of Colorado, Boulder |
16 | A Phase 1, Randomized, Open-Label, Parallel-Design, Multicenter Study to Evaluate the Pharmacokinetics, Safety, and Pharmacodynamics of Dexlansoprazole Delayed-Release Capsules in Infants Aged 1 to 11 Months With Acid-Related Diseases | Pediatric Gastroesophageal Reflux Disease | Israel, Italy, Mexico, Poland, United States | 2025 | 0 | Dexlansoprazole | Takeda |
17 | Data on the Prevention of Complications of Prophylactic Intravenous Hydration in Patients With Estimated Glomerular Filtration Rate (eGFR) < 30 ml/Min/1.73m2 From the Maastricht UMC+ Contrast Voorbereidings Polikliniek | Acute Kidney Injury (Nontraumatic), Contrast-induced Nephropathy | 2025 | 500 | CVP screening | Maastricht University Medical Center | |
18 | Efficacy of Point-of-care Creatinine Assays in Patients With eGFR <30ml/Min/1.73m2 in the Setting of Elective Procedures With Intravascular Iodinated Contrast | Acute Kidney Injury, Contrast-induced Nephropathy, Renal Insufficiency | 2025 | 1 100 | serum creatinine assay | Maastricht University Medical Center | |
19 | A Phase I/II, Randomized, Placebo-Controlled Study of the Safety and Efficacy of Transendocardial Injection of Autologous Human Cells (Mesenchymal or the Combination of MSC and Cardiac Stem Cells) in Patients With Chronic Ischemic Left Ventricular Dysfunction and Heart Failure Secondary to Myocardial Infarction. | Chronic Ischemic Left Ventricular Dysfunction, Myocardial Infarction | United States | 2025 | 0 | Autologous hMSCs, Autologous Human C-Kit CSCs II, Biosense Webster MyoStar NOGA Injection Catheter System, Placebo | University of Miami |
20 | Evaluation of Indocyanine Green-guided Systematic Pelvic Lymphadenectomy in Endometrial and Cervical Cancer | Cervical Cancer, Endometrial Cancer | 2025 | 100 | Indocyanine green-guided systematic pelvic lymphadenectomy | Università degli Studi dell'Insubria | |
21 | Phase 1B Study of APVO436 in Combination With Venetoclax and Azacitidine in Elderly or Unfit Patients With Newly Diagnosed Acute Myeloid Leukemia (AML) | AML | 2025 | 0 | APVO436 | Aptevo Therapeutics | |
22 | Phase IIA, Single-Center, Single-Arm Clinical Study of OMN54 (Aneustat) in Men Diagnosed With Prostate Cancer Being Followed by Active Surveillance | Prostate Cancer | 2025 | 0 | OMN54 | Omnitura Therapeutics, Inc. | |
23 | Decision-Making Experiences for Culturally Inclusive Dementia Engagement: Dyads and Families (DECIDE: Dyads and Families) | Alzheimer Disease, Caregiver Burden, Dementia | 2024 | 40 | Prototype Intervention | Emory University | |
24 | A Pilot Randomized Controlled Trial of ED-TREAT (Early Detection and Treatment to Reduce Events With Agitation Tool) Compared to Usual Care | Behavioral Disorder, Psychomotor Agitation | United States | 2024 | 26 | ED-TREAT | Yale University |
25 | Influence of the Design of the Transmucosal Abutment on the Marginal Periimplant Bone Loss. Randomized Clinical Trial | Peri-implant Bone Level, Peri-implant Bone Loss, Peri-implant Marginal Bone Loss, Transmucosal Abutment Design | Spain | 2024 | 36 | Conventional transmucosal abutment design, Narrow transmucosal abutment design | University of Santiago de Compostela |
26 | Periodontal Management in Hypertensive Patients | Gingivitis, Hypertension, Periodontal Diseases | 2024 | 100 | electric toothbrush, Professional oral hygiene | University of L'Aquila | |
27 | The Impact of Light Intensity in Home Workplaces on Health and Well-being of Remote Office Workers | Alertness, Daytime Cognitive Performance, Sleep | 2024 | 36 | Bright lighting, Placebo lighting | University of Wisconsin, Madison | |
28 | Improving Safety of Cardiovascular Implantable Electronic Devices in Veterans (CDA 21-057) | Patient Safety | United States | 2024 | 12 | Academic detailing and audit and feedback intervention | VA Office of Research and Development |
29 | AlloLife - Life After Allogeneic Hematopoietic Stem Cell Transplantation | Stem Cell Transplant Complications, Survivorship | 2024 | 192 | Technology supported, coordinated survivorship care using wearable devices, supportive patient-apps and cardio-oncology physician apps | University Hospital, Essen | |
30 | Development of a Multi-sensory Rehabilitation Program for People With Ultra Low Vision | Functional Visual Loss, Low Vision Blindness, Quality of Life, Visual Impairment | 2024 | 36 | Multimodal training, Visual Information Training | Johns Hopkins University | |
31 | Evaluation of Mechanisms Responsible for Coma in Patients Affected by Fulminant, Acute and Chronic Hepatic Failure | Acute and Chronic Hepatic Failure With Developing Coma | United States | 2024 | 20 | The University of Texas Medical Branch, Galveston | |
32 | Pilot Clinical Study Using Pre-operative Simulation for Patients Undergoing Cochlear Implant | Sensori-Neural Deafness | 2024 | 20 | Pre operative computer based cochlear implant surgical simulation | Nationwide Children's Hospital | |
33 | Preventing Childhood Asthma Using Prophylactic House Dust Mite Allergen Immunotherapy | Allergy, Asthma | 2024 | 270 | HDM sublingual Immunotherapy, Placebo | Boston Children's Hospital | |
34 | A Phase 1b/2a, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety of ATR-04 to Reduce the Severity of Epidermal Growth Factor Inhibitor Associated Papulopustular Rash | Epidermal Growth Factor, Papulopustular Rosacea | United States | 2024 | 60 | ATR-04, Placebo | Azitra Inc. |
35 | A Pilot Feasibility Study of Intramuscular Oxytocin on Fear of Pain and Trust in Physical Therapist During Outpatient Rehabilitation After Total Knee Arthroplasty | Osteoarthritis, Knee | United States | 2024 | 0 | Oxytocin, Placebo | Wake Forest University Health Sciences |
36 | Apply the Pharmacodynamic Model of Peripheral Oxytocin Action to a Multimodal Stimulus That Increases (Heat) or Decreases (Vibration) Pain Perception | Pain, Chronic | United States | 2024 | 30 | Oxytocin, Placebo | Wake Forest University Health Sciences |
37 | To Implement and Test the Mobile Monitoring Tool to Identify SSI (R33 Phase) | Orthopedic Disorder | 2024 | 500 | Mobile Monitoring Tool | Stanford University | |
38 | Evaluating the Effectiveness of Different Targeting Approaches for Transcranial Magnetic Stimulation Treatment of Depression | Depression | United States | 2024 | 60 | Mixed reality neuronavigation, Transcranial Magnetic Simulation | Stanford University |
39 | A Randomized Controlled Trial to Evaluate an EHR-based PAD Screening Tool | Peripheral Artery Disease, Peripheral Vascular Disease | United States | 2023 | 50 | High PAD risk Alert | Stanford University |
40 | Clinical and Radiographic Outcomes of CAD/CAM Versus Conventionally Constructed Occlusal Splints in Patients With Temporomandibular Joint Disorders: A Randomized Clinical Trial | Temporomandibular Disorder | 2023 | 20 | CAD/CAM splints | Cairo University | |
41 | A Phase III, Double-Blind, Randomized, Vehicle-Controlled, Parallel-Group, Multicenter Evaluation of Civamide Nasal Solution 0.01% in the Prevention of Cluster Headaches During an Episodic Cluster Headache Period | Episodic Cluster Headache | 2023 | 180 | Civamide nasal solution 0.01% | Winston Laboratories | |
42 | Survey of Dysmorphic Uterus Knowledge Among Gynecologists. | Dysmorphic Uterus | 2023 | 300 | Survey | Università degli Studi dell'Insubria | |
43 | Use of Functional Near-infrared Spectroscopy to Investigate Role of Human Auditory Cortex Plasticity and Multi-sensory Integration on Cochlear Implant Performance After Single-sided Deafness | Hearing Loss | 2023 | 75 | FNIRS Observational | University of Michigan | |
44 | Preemptive US Guided Brachial Plexus Blockade Can Reduce Postoperative Pain. A Randomized Trial | Postoperative Pain, Rotator Cuff Injuries | Brazil | 2023 | 70 | Preemptive group, Regular group | University of Sao Paulo General Hospital |
45 | Anlotinib Hydrochloride Combined With Capeox in the Neoadjuvant Treatment of Locally Advanced Rectal cancer-a Prospective, Open, Single Center and Randomized Controlled Phase Ⅱ Clinical Trial | Anlotinib, Neoadjuvant Treatment, Rectal Cancer | 2023 | 0 | Anlotinib+Capeox, Capeox | Shanghai Minimally Invasive Surgery Center | |
46 | Effect of Antibiotics on Urinary Microbiome: Randomized Trial | Antibiotic Resistant Infection, Antibiotics Causing Adverse Effects in Therapeutic Use, Bacteriuria, Microtia, UTI | 2023 | 0 | Bactrim DS 800Mg-160Mg Tablet, Placebo oral tablet | Johns Hopkins University | |
47 | Evaluation of Reproductive Outcomes After Different Management of Ovarian Endometrioma Prior to Assisted Reproduction Technology (ART): Laparoscopic Enucleation Vs Prolonged Pituitary Downregulation With Gonadotropin Releasing Hormone (GnRH)-Agonists | Infertility, Female, Ovarian Endometrioma | 2023 | 100 | Assisted Reproductive Technology (ART), Laparoscopic enucleation of ovarian endometrioma., Prolonged pituitary downregulation | Università degli Studi dell'Insubria | |
48 | Nanoencapsulated Cannabidiol Time Released Capsules Targeted to Reduce Cravings in the Treatment of Opioid Addiction | Addiction, Opioid Dependence, Opioid Withdrawal | 2023 | 32 | APH-1501, Placebo | Aphios | |
49 | Preventing Alcohol Misuse and Consequences in Vulnerable Women | Alcohol Drinking | United States | 2023 | 70 | Behavioral: Health Coaching (HC), Behavioral: Motivational Interview (MI) | The Miriam Hospital |
50 | An Open-label, Multi-center, Phase 4 Study of XGEVA® (Denosumab) in Chinese Adults and Skeletally Mature Adolescents With Giant Cell Tumor of the Bone | Giant Cell Tumor of Bone | 2023 | 35 | XGEVA® | Amgen |